During the 1980s in Palermo, the new and extremely lucrative business of the mafia is the drug trade which the bosses import from Thailand, refining them and then sending them under the form of heroine to their relatives in America. The Corleonesi who do not have contacts in the USA are forced to rely on the Palermo bosses so as to gain a slice of the action from time to time. This subjection does not go down well with Riina. His anxiety does not escape the mafia heads Bontate and Inzerillo who rebuke Masino Buscetta for having brought u Curtu, as they contemptibly call him, into the Commission. Riina, who has ingratiated himself with the lower level Mafiosi belonging to the other families in the province by means of money and gifts, is ready to go to war. Biagio, in the meanwhile, is working alongside Boris Giuliano whose investigations lead to the discovery of the mafia refineries and the arrest of the mafia chemist Francesco Marino Mannoia. When, however, Giuliano tries to turn the screws on and obtains authorization to inspect the bank accounts of the bosses, Riina orders his brother-in-law, Luchino Bagarella, to kill him. The death of the police chief, Boris Giuliano, throws Biagio into turmoil. In the meantime Teresa, who has just discovered that she is pregnant, goes to a clinic in Palermo for an appointment. But she finds Ninetta Bagarella in the same hospital, who has just given birth to her third child, and the two women meet in the corridor. Teresa, in a panic, calls Biagio while she escapes through the streets of Palermo. Ninetta, in turn, abandons the hospital in a hurry. Due to the shock, Teresa loses the baby but this time leaves Palermo and moves to Rome with little Antonio. In the meantime, the mafia war against the State continues, grimly marked by the murder of the judges Terranova and Costa, and Riina, despite the perplexities expressed by Binnu, also kills the bosses Bontate and Inzerillo wiping out the families thanks to the information of their lower ranks. Buscetta, who had for some time foretold the end of Cosa Nostra, escapes to Brazil. While Biagio is totally alienated at police headquarters and must return to the Corleone passport office, Riina has achieved his goal: he is now the greatly feared boss of the Sicilian mafia and with Michele Greco meets John Gambino who is the head of the American mafia. Together with the latter, who is passing through Sicily, he comes to terms and suggests alliances.