This year's Mark Twain Prize goes to renowned comedic playwrite/screenwriter, Neil Simon. This special features tributes and comic testimonials from a star-studded cast of Neil Simon's friends and colleagues, including Jason Alexander, Christina Applegate, Lucie Arnaz, Matthew Broderick, Richard Dreyfuss, Heather Headley, Patricia Heaton, Jane Kaczmarek, Robert Klein, Nathan Lane, Robert Redford, Paul Reiser, Jonathan Silverman and Allen Toussaint. The program also includes an assortment of classic film clips from Simon's career.