Infections caused by organisms such as bacteria, viruses or fungi are a normal part of life. However, a pattern of frequent and recurring infections is not - such as pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin and blood infections. The reason for these frequent occurrences may be a condition known as, primary immunodeficiency. The result can be a compromised immune system which can be serious, lead to chronic illness, permanent organ damage, or even death. Because these frequent infections are longer lasting and often harder to treat than those that occur in a normally functioning immune system, it's critical to detect, diagnose and treat primary immunodeficiency before it becomes a serious problem. In this program we will study the science behind primary immunodeficiency. We'll also learn how doctors help patients deal with this disorder, and, how patients can live normal productive lives when PI is properly managed.