NOVA investigates the extraordinary impact music can have on the human brain, through the case studies from neurologist Dr. Oliver Sacks' latest book Musicophilia. We travel around the globe to meet people like Tony Cicoria, who was struck by lightning and was suddenly inspired to become a pianist; and Matt Giordano, who uses drumming to alleviate his severe Tourettes. NOVA even peers deep into the brain of Dr. Sacks himself, in a rare glimpse of what makes minds musical.