In 2006, art collector and entrepreneur Steve Wilson opened the first 21c Museum Hotel in Louisville, Ky., a unique hybrid of a boutique hotel and gallery space where visitors can experience world-class contemporary art without the cost of museum admission. IN FRAME: THE MAN BEHIND THE MUSEUM HOTELS follows Wilson for more than a year as he builds his latest Museum Hotel in Durham, N.C., navigating a maze of art fairs and construction sites to bring his artistic vision to life.