Senior registrar Kate Dickenson's (Ashley Jensen) promotion to superintendent is about to be announced and she knows that her colleague Judy (Rebecca Front), who was competing for her for the promotion, will not be happy with the news. Kate is enjoying a secret affair with her colleague Rick. Kate arranges the marriage of terminally ill Jenny to the father of her baby, Simon. Jenny dies after the wedding. Kate thinks that pregnant Slovenian Kristina's forthcoming marriage to Iranian student Amir is either bogus or forced. No-one is prepared for her colleague James (Mark Stanley) arriving at her house, then telling her that he is transitioning into being a woman called Jamie and that he will from now on be wearing women's clothes. Kate is alarmed to discover that her teenage daughter is hiding suspicious messages on her mobile phone. Kate's policeman partner Rob Armstrong's (Adrian Bower) son Liam unexpectedly comes to stay at the house putting the household under pressure.