Genesis: The Last Domino? follows Tony Banks, Phil Collins and Mike Rutherford as they rehearse for a return to touring. Despite the complications and uncertainties of the global Covid-19 pandemic, and without confirmed performance dates, the band undertook preparations for a major return to the stage after a 17 year absence. The film focuses on the creative and emotional process involved in their reunion and features live performances, along with interviews with the band and support team. Viewers get a keen insight into what it takes to prepare a major rock show during extraordinary circumstances. Songs performed include "Mama", Land of Confusion", Throwing It All Away" and other Genesis classics.