This moving biographical drama follows the life of revered baseball player Lou Gehrig (Gary Cooper). Championed by sportswriter Sam Blake (Walter Brennan), Gehrig eventually gets recruited by the New York Yankees, joining a team of heavy hitters that includes the legendary Babe Ruth. When Gehrig marries his spirited sweetheart, Eleanor (Teresa Wright), things look up for him, but he is soon sidelined by a terrible illness that he bravely tries to battle.