It has been over ten years since the publication of Dr. Perricone's first book The Wrinkle Cure. In that book, I introduced the concept that inflammation is at the basis of aging and age-related disease. This inflammation exists in a broad spectrum that ranges from low to high. On the low side, it occurs on a cellular level and is invisible to the naked eye. It can only be discerned microscopically or sub-microscopically on a molecular level. On the high side, the inflammation is visibly evident as redness and swelling such as seen in a wound or sunburn. The concept of the inflammation/aging/disease theory was vigorously resisted at that time by both my colleagues and mainstream medicine in general. Fortunately, a great deal has changed in a decade, and since that time, numerous studies have validated this concept. Many therapeutic interventions are now being developed to counteract sub-clinical inflammation and thereby prolong both our health and our lifespan.