Host David Yetman joins Herpatologists (reptile and amphibian researchers) in their various quests to learn more about the many venomous creatures that call the Sonoran Desert home. During the day, they track Tiger Rattlesnakes using radio implants before heading up to the mountains to observe other rattlesnake dens. At night, while studying the impact urban developments have on the movements of a Gila Monster, they encounter rattlesnakes, tarantulas, and desert toads.