Mike and Willie are challenged to investigate the microbial world of germs and discover which places in Mike's house are the "germiest." With the help of a public health expert, the boys swab several locations in Mike's house. Then, they head off to a lab to grow the germs in culture and analyze the growth of bacteria to determine which place has the most germs. Meanwhile Nina and Madi visit a chocolate factory and learn how to make candy. The girls quickly learn that it's not as easy as it looks, and that they must work together to accomplish their challenge.